I've been running funtoo on my ASUS N56V for over 2 years now. One thing I bump into time and again is my mouse (Logitec M325) which doesn't always respond well. I have essentially 3 use cases (2 broken one working)
1. After boot, the mouse is generally not too reliable and lags quite a bit every now and then
2. If after boot, I pull the wireless dongle out and reinsert it, the mouse is stable until the next boot.
3. Whenever I run purely on battery, the mouse is often non-responsive or lags quite a bit. Incidentally, the touch pad works just fine.
I'd love to resolve some of these issues, but I'm not sure where to start. I used to run laptop-mode but turned it off, since on battery it was spinning my drive down a lot. So as far as I know I'm not running any fancy software that turns things off when I'm only on the battery.
For what its worth, i'm running the Awesome WM.